A newly published preclinical study in Communications Biology adds to the growing scientific interest in NAD+ and healthy ageing. The paper, titled “NAD+ controls circadian rhythmicity during cardiac aging”, looked at how age-related declines in cardiac NAD+ may affect the heart’s internal daily rhythms, and whether NAD+ precursor supplementation could help restore some of those patterns in older mice. The study is currently available as an article in press / early access version.
If you’d like to read the study itself, you can view it here: published study
As we age, levels of NAD+ tend to decline. NAD+ is involved in cellular energy production and is also closely linked to sirtuins, mitochondrial function, and circadian biology.
In this study, researchers examined ageing in female mice and found that cardiac NAD+ decreased with age. They then explored how this decline affected the rhythmic activity of genes in heart tissue over the 24-hour cycle.
In simple terms, the study looked at whether lower NAD+ may contribute to a less “youthful” daily rhythm in the ageing heart, and whether restoring NAD+ could help.
According to the journal summary, the researchers found that ageing-related drops in cardiac NAD+ were associated with changes in the rhythmicity of transcription in the heart, and that this was partially restored by NAD+ precursor supplementation. The study specifically used nicotinamide riboside (NR) as the NAD+ precursor.
That does not mean NR has been proven to improve heart ageing in humans. But it does add another interesting piece to the broader NAD+ puzzle.
This study is notable for two reasons:
Circadian rhythm is the body’s internal 24-hour timing system. When these rhythms become disrupted with age, it may affect how tissues function and recover.
This is the key point.
This was a preclinical animal study, not a human clinical trial. That means the findings are interesting and worth following, but they should be viewed as early-stage evidence, not proof of a direct human benefit.
At MyVitality, we think this kind of research is useful because it helps show where the science is heading, but we always try to be clear about the difference between promising preclinical data and proven human outcomes.
What we like about this study is that it adds to the growing body of research around NAD+ support during ageing, and in this case it specifically used nicotinamide riboside (NR).
For customers interested in supporting NAD+ levels, NR is another well-known NAD+ precursor, alongside NMN. Some people also like that NR can be a more affordable entry point into the NAD+ category.
If you’re curious about NR, our MyVitality Nicotinamide Riboside (NR) is:
No. This was a mouse study, not a human clinical trial. It suggests that declining cardiac NAD+ may affect age-related circadian patterns in the heart, and that NR supplementation may partially restore some of those changes in older mice. It’s promising early research, but not proof of a human benefit.
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