CA-AKG: Supporting Healthy Ageing with Science-Backed Nutrients

At MyVitality, our mission is to help New Zealanders enjoy longer, healthier, and more vibrant lives through science-backed nutrition. One of the most exciting compounds in healthy ageing research today is Calcium Alpha-Ketoglutarate (CA-AKG) — a stable, bioavailable form of alpha-ketoglutarate that plays a central role in energy metabolism, cellular repair, and overall vitality.

As we age, natural levels of AKG decline. Supplementing with CA-AKG offers a way to replenish this important nutrient and may support healthier ageing at the cellular level.

What is CA-AKG?

Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle, the process that allows our cells to convert nutrients into energy. Beyond energy production, AKG supports collagen formation, amino acid balance, bone health, and epigenetic regulation (the way genes are expressed).

The calcium salt form, CA-AKG, is more stable and easier for the body to absorb — making it a promising dietary supplement for anyone interested in supporting healthy ageing.

Research on CA-AKG and Healthy Ageing

Animal Studies

• A landmark 2020 study in mice found that CA-AKG not only extended lifespan but also improved healthspan — the number of years lived in good health. Mice supplemented with CA-AKG showed less frailty, reduced inflammation, and better overall function.
• Other studies show AKG helps maintain muscle and connective tissue, supports mitochondrial health, and lowers age-related inflammation markers.

Human Evidence

• A 2021 pilot study in humans reported that participants taking Ca-AKG with supporting nutrients experienced an average reduction of eight years in biological age, as measured by advanced DNA methylation clocks.
• Current clinical trials, including the ABLE study, are underway to test Ca-AKG’s effects on ageing in larger populations. Early results are encouraging, but more research is needed to confirm long-term benefits.

How CA-AKG May Work

Scientists believe CA-AKG supports healthy ageing through several mechanisms:

• Reducing inflammation – balancing immune responses and lowering chronic inflammatory signals.
• Supporting epigenetic health – helping maintain healthy patterns of gene expression.
• Promoting tissue repair – contributing to collagen and protein synthesis for bone, skin, and muscle integrity.
• Boosting energy metabolism – keeping mitochondria, the “powerhouses of the cell,” working efficiently as we age.

Why Choose MyVitality CA-AKG?

At MyVitality, we are proud to manufacture and bottle all of our supplements in New Zealand, following the highest quality standards. Our CA-AKG is formulated to provide reliable support for people who want to:

• Maintain vitality and resilience as they age.
• Support cellular health and metabolic balance.
• Complement a lifestyle that already includes good nutrition, exercise, and rest.

By choosing MyVitality, you’re not only supporting your own health but also a locally owned New Zealand company committed to healthy ageing backed by science.

The Bottom Line

While ageing is a natural process, research suggests Ca-AKG can help us age more gracefully — supporting energy, resilience, and overall wellbeing. Animal studies show strong benefits, and early human research points toward reductions in biological age.

At MyVitality, we believe Ca-AKG is an exciting addition to a healthy ageing toolkit — alongside balanced nutrition, regular movement, and quality sleep. As research progresses, we look forward to seeing even more evidence for this remarkable nutrient.

Explore our New Zealand-made CA-AKG supplement today and take a science-backed step towards healthier ageing.