As we age, our body’s ability to maintain and repair itself gradually slows down. At the heart of this process lies a molecule called NAD⁺ (nicotinamide adenine dinucleotide) — a coenzyme essential for energy production, DNA repair, and overall cellular function. Levels of NAD⁺ decline naturally with age, which can contribute to tiredness, slower recovery, and reduced vitality.
How NMN Supports Healthy NAD⁺ Levels
NMN (nicotinamide mononucleotide) is a direct precursor to NAD⁺. Supplementing with NMN helps restore the body’s natural NAD⁺ pool, supporting energy metabolism and the repair of age-related cellular damage. Studies in animals and humans show NMN can help enhance physical endurance, support vascular health, and improve mitochondrial efficiency — the way our cells generate energy. NAD⁺ also activates sirtuins — longevity-related proteins that regulate gene expression, stress resilience, and inflammation response. Maintaining adequate NAD⁺ levels through NMN supplementation may therefore support healthier ageing from within.
Why TMG Complements NMN
While NMN helps build NAD⁺, it also increases demand for methyl groups — essential chemical units used in countless biological reactions. This is where TMG (trimethylglycine, also known as betaine) plays a crucial role. TMG donates methyl groups to help recycle homocysteine back into methionine, keeping the body’s methylation cycle in balance.
Every day, your cells repair tiny breaks in their DNA caused by stress, oxidation, and normal metabolism. NMN supports this process by boosting NAD⁺, which activates DNA-repair enzymes. At the same time, TMG provides methyl groups that help rebuild and stabilise DNA strands and maintain balanced gene activity. Together, they support the body’s natural ability to repair, renew, and regulate the genes linked with healthy ageing.
Your liver works hard to filter toxins and process nutrients. TMG supports this by donating methyl groups that help convert harmful compounds into forms the body can safely remove. By improving methylation and liver function, TMG helps keep your detox pathways clear and your energy levels steady.
Healthy methylation is vital for producing neurotransmitters like dopamine and serotonin, which influence mood, focus, and motivation. TMG supports this methylation process, while NMN boosts cellular energy, helping brain cells function at their best. Together they promote clearer thinking, balanced mood, and sustained mental performance.
As NMN raises NAD⁺ levels for energy and cellular repair, it also increases the demand for methyl groups in the body. TMG replenishes these methyl stores, ensuring NAD⁺ can be produced efficiently without depleting other essential pathways. This synergy helps NMN work more effectively and supports long-term cellular balance.
When taken together, NMN and TMG work synergistically: NMN boosts NAD⁺ for energy and repair, while TMG supports the methylation pathways that keep NAD⁺ production sustainable.
New Zealand‑Made Quality You Can Trust
MyVitality’s NMN and TMG supplements are formulated and bottled in New Zealand under strict quality standards, using premium ingredients backed by scientific research. This pairing offers a practical, science‑based approach to supporting natural energy, focus, and longevity.
Who It’s For
Combining NMN with TMG offers a simple yet powerful way to support your body’s most fundamental systems — energy, repair, and renewal — from the inside out.
Written by Stephen at MyVitality
References & Further Reading
Yoshino, M. et al. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science, 372(6547), 1224–1229. DOI: 10.1126/science.abe9985 (Free full text) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550608/
Mills, K.F. et al. (2016). Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metabolism, 24(6), 795–806. DOI: 10.1016/j.cmet.2016.09.013 (Free full text) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668137/
Schwab, U. et al. (2002). Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. American Journal of Clinical Nutrition, 76(5), 961–967. DOI: 10.1093/ajcn/76.5.961 https://doi.org/10.1093/ajcn/76.5.961
Craig, S.A.S. (2004). Betaine in human nutrition. American Journal of Clinical Nutrition, 80(3), 539–549. DOI: 10.1093/ajcn/80.3.539 https://pubmed.ncbi.nlm.nih.gov/15321791/
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